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DA-depleting agents and DA receptor antagonists effectively reduce abnormal movements in HD 3,4 , demonstrating the contribution of DA to motor dysfunction

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Neuronal mitochondrial dysfunction and central hypometabolism not only impair synaptic plasticity in cognitive-related brain regions but also further promote the release of neuronal DAMPs (e.g., mtDNA), which can activate local microglia in the central nervous system, forming a central energy-inflammation positive feedback loop